Persistent Symptoms and IFN-γ-Mediated Pathways after COVID-19

After COVID-19, patients have reported various complaints such as fatigue, neurological symptoms, and insomnia. Immune-mediated changes in amino acid metabolism might contribute to the development of these symptoms. Patients who had acute, PCR-confirmed COVID-19 infection about 60 days earlier were recruited within scope prospective CovILD study. We determined inflammatory parameters alterations tryptophan phenylalanine 142 cross-sectionally. Symptom persistence (pain, gastrointestinal anosmia, sleep disturbance, symptoms) patients’ physical levels functioning recorded. Symptoms improved many after acute (n = 73, 51.4%). Still, a high percentage complaints, women affected more often. In patients, ongoing immune activation (as indicated by neopterin CRP concentrations) enhanced catabolism found. A higher tyrosine ratio (Phe/Tyr) was found with lower level functioning. improvements pain Phe/Tyr ratios, while symptoms presented kynurenine values. Our results suggest that persistent often than men. addition, certain appear be associated immune-mediated metabolism.